Hemant Pawar

Hemant Pawar, PhD.

Research Investigator

Phone: (734) 647-5843

Fax: (734) 647 0228

Research Interests

The focus of my research is molecular genetics of glaucoma with a major interest in a disease called nanophthalmos. Nanophthalmos is an ocular malformation in which the eye is reduced in size. It is a defect that occurs late in the development of the eye. Affected individuals experience significant correctable visual disability from angle closure glaucoma.

Dr. Richard's group has localized the gene for an autosomal dominant form of this disease (NNO1) at chromosome 11q. I am using a candidate positional cloning strategy to find the genetic defect in NNO1. Finding the NNO1 gene will also lead to information about other genes that interact with the NNO1 gene and the steps involved both upstream and downstream of this gene. This will add to our understanding of the developmental stages of the eye that are currently not well understood.

Education

National Chemical Laboratory, Pune, India. Ph.D. in Biochemistry (1989).
Marathwada University, India. MS in Biochemistry (1983).

Select Publications

Tsuchiya N, Kondo Y, Takahashi A, Pawar H, Qian J, Sato K, Lieber MM, Jenkins RB (2002). Mapping and gene expression profile of the minimally overrepresented 8q24 region in prostate cancer. Am J Pathol 2002 May;160(5):1799-806
K. T. Hiriyanna, Eve L. Bingham, Christina McHenry, H. S. Pawar, Caraline Coats, Thomas Darga, Julia E. Richards and Paul A. Sieving (The Retinoschisis Consortium) , Hum. Mol. Genet, 1998, 7(7), 1185-1192; Functional implications of the spectrum of mutations found in 234 cases with X-linked juvenile retinoschisis (XLRS).
P. A. Sieving, S. Boskovich, E. Bingham and H. S. Pawar, Tr. Am. Ophth. Soc., 1996 Vol XCIV, 275-297; Sorsby's fundus dystrophy in a family with SER-181-Cys mutation in the TIMP-3 gene: poor outcome after laser photocoagulation.
H. S. Pawar, E. L. Bingham, K. Hiriyana, M. Segal, J. E. Richards, P. A. Sieving, Human Heredity, 1996, 46, 329-335; X-linked Retinoschisis maps between (DXS1195,DXS418) and AFM291wf5 on a single YAC.
Y. Hoe, J. E. Richards, E. L. Bingham, H. S. Pawar, K. Scott, M. Segal, K. L. Lunetta, M. Boehnke and P. A. Sieving, Human Heredity, 1996, 46, 211-220; Linkage study of Best's Vitelliform Macular Dystrophy (VMD2) in a large North American Family.
H. S. Pawar, E. L. Bingham, K. L. Lunetta, M. Segal, J. E. Richards, M. Boehnke, P. A. Sieving, Human Heredity, 1995, 45, 206-210; Refined genetic mapping of Juvenile X-linked Retinoschisis.
J. Tombran-Tink, H. S. Pawar, A. Swaroop and G. J. Chader, Genomics, 1994, 19(2), 266-272; Localization of the gene for pigment epithelium derived factor to chromosome 17p13.1 and expression in cultured human retinoblastoma cells.
H .S. Pawar and D. R. Deshmukh, Preparative Biochemistry, 1994, 27(2), 143-150; Immobilization of D-xylose(D-glucose) isomerase from Chainia sp.
A. Swaroop, J. Xu, H. S. Pawar, A. Jackson, C. Skolnick and N. Agarwal, Proceedings of National Academy of Sciences (USA), 1992, 82, 266-270; A conserved retina specific gene encodes a basic motif/leucine zipper domain.

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