Edward H. Trager

Bioinformatics Programmer

Phone: (734) 764-0059

Fax: (734) 647 0228

Research Interests

I provide bioinformatics programming support to the Richards research group. My research focuses on developing integrated solutions to streamline the research data pipeline, improve data quality, and reduce error rates. I strive to understand problems globally before implementing solutions. Two areas of current research related to genome-wide human linkage studies are:

Developing better methods for automated allele binning and error detection, and:
Developing better methods for visualizing haplotyping results.

Two programs which incorporate products of my research are:

Cicada, a web-based database system for acquisition, storage, verification, normalization, quality control, and management of genetic marker information. This system now includes an interactive, histogram-based editor for verifying and editing allele calls.
Madeline, a program for preparing, visualizing, and exploring human pedigree data used in genetic linkage studies.

Education

University of Michigan School of Natural Resources and Environment, Ann Arbor, MI. MS in Forest Ecology and Management (1997). Thesis: Comparative morphology of red oak taxa in ecologically distinct ecosystems in Lower Michigan. Advisor: Dr. Burton V. Barnes. .
Johns Hopkins University School of Advanced International Studies (SAIS) and Nanjing University Center for Chinese and American Studies (), Nanjing, China. One-year graduate certificate program in international relations (1987).
Oberlin College, Oberlin, Ohio. East Asian Studies major, Chinese Language and Literature concentration. Junior year abroad at the Center for Chinese Language and Cultural Studies (Mandarin Training Center), National Taiwan Normal University, Taipei. B.A. (1986).

Publications

In Preparation

Botanical illustrations in Barnes, B.V., Michigan Trees (revised edition). University of Michigan Press.
Madeline v. 0.935. Software program documentation [2002].

Peer-reviewed

Goncalo R. Abecasis, Beverly M. Yashar, Yu Zhao, Noor M. Ghiasvand, Sepideh Zareparsi, Kari E. H. Branham, Adam C. Reddick, Edward H. Trager, Shigeo Yoshida, John Bahling, Elena Filippova, Susan Elner, Mark W. Johnson, Andrew K. Vine, Paul A. Sieving, Samuel G. Jacobson, Julia E. Richards, and Anand Swaroop (2004) Age-Related Macular Degeneration: A High-Resolution Genome Scan for Susceptibility Loci in a Population Enriched for Late-Stage Disease . Am. J. Hum. Genet., 74:482-494.
Ghosh, S., Watanabe, R.M., Valle, T., Hauser, E.R., Magnuson, V.L., Langefeld, C.D., Ally, D.S., Mohlke, K.L., Silander, K., Kohtamaki, K., Chines, P., Balow, J., Birznieks, G., Chang, J., Eldridge, W., Erdos, M.R., Karanjawala, Z.E., Knapp, J.I., Kudelko, K., Martin, C., Morales-Mena, A., Musick, A., Musick, T., Pfahl, C., Porter, R., Rayman, J.B., Rha, D., Segal, L., Shapiro, S., Sharaf, R., Shurtleff, B., So, A., Tannenbaum, J., Te, C., Tovar, J., Unni, A., Welch, C., Whiten, R., Witt, A., Blaschak-Harvan, J., Douglas, J.A., Duren, W.L., Epstein, M.P., Fingerlin, T.E., Kaleta, H.S., Lange, E.M., Li, C., McEachin, R.C., Stringham, H.M., Trager, E., White, P.P., Eriksson, J., Toivanen, L., Vidgren, G., Nylund, S.J., Tuomilehto-Wolf, E., Ross, E.H., Demirchyan, E., Hagopian, W.A., Buchanan, T.A., Tuomilehto, J., Bergman, R.N., Collins, F.S., and Boehnke, M. (2000) The Finland-United States Investigation of Non-Insulin-Dependent Diabetes Mellitus Genetics (FUSION) Study. I. An Autosomal Genome Scan for Genes that Predispose to Type 2 Diabetes. American Journal of Human Genetics 67:1174-1185.
Watanabe, R.M., Ghosh, S., Langefeld, C.D., Valle, T., Hauser, E.R., Magnuson, V.L., Mohlke, K.L., Silander, K., Ally, D.S., Chines, P., Blaschak-Harvan, J., Douglas, J.A., Duren, W.L., Epstein, M.P., Fingerlin, T.E., Kaleta, H.S., Lange, E.M., Li, C., McEachin, R.C., Stringham, H.M., Trager, E., White, P.P., Balow, J., Birznieks, G., Chang, J., Eldridge, W., Erdos, M.R., Karanjawala, Z.E., Knapp, J.I., Kudelko, K., Martin, C., Morales-Mena, A., Musick, A., Musick, T., Pfahl, C., Porter, R., Rayman, J.B., Rha, D., Segal, L., Shapiro, S., Sharaf, R., Shurtleff, B., So, A., Tannenbaum, J., Te, C., Tovar, J., Unni, A., Welch, C., Whiten, R., Witt, A., Kohtamaki, K., Ehnholm, C., Eriksson, J., Toivanen, L., Vidgren, G., Nylund, S.J., Tuomilehto-Wolf, E., Ross, E.H., Demirchyan, E., Hagopian, W.A., Buchanan, T.A., Tuomilehto, J., Bergman, R.N., Collins, F.S., and Boehnke, M. (2000) The Finland-United States Investigation of Non-Insulin-Dependent Diabetes Mellitus Genetics (FUSION) Study. II. An Autosomal Genome Scan for Diabetes-Related Quantitative-Trait Loci. American Journal of Human Genetics 67:1186-1200.

Other

Madeline. Software program documentation [FUSION, 1999].
Comparative morphology of red oak taxa in ecologically distinct ecosystems in Lower Michigan. Master's thesis, 1997.

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